Handling Low-Yield FFPE Samples: Tips for Successful Library Prep

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Handling Low-Yield FFPE Samples: Tips for Successful Library Prep Wet Lab Insights · Jun 11, 2026 Home > Blog > Handling Low-Yield FFPE Samples: Tips fo...

Wet Lab Insights 11 June 2026

Short Bio: Core expert in high-throughput library preparation and flow cell loading. Manages day-to-day operations and routine calibration for Illumina NovaSeq systems.
Excerpt: Formalin-Fixed Paraffin-Embedded (FFPE) tissue samples are notorious for DNA degradation. In this guide, I share our lab's updated protocol for maximizing extraction yields, managing low 260/280 quality ratios, and adjusting PCR cycles to save precious clinical samples from failure.

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